New IoT applications will enable autonomous health monitoring and interventions by carefully preserving the privacy and security of patients’ data and providing trust assurance. Patients will be engaged via a rehabilitation program e.g. heart failure patients or patients recovering from cardiac arrests. They can use sensors and devices without being limited to their home or to the hospital for carrying out the rehabilitation. This way, patients can re-immerse into their normal environment safely and quicker than what is currently possible, or they can be treated remotely in order to reduce the risk of further infection. Clinicians act as human-in-the-loop, receive updates from the IoT-supported solution, and are notified when their intervention is required.